Modelling and Experimental validation of Powder Flow for Pharmaceutical Materials

Researcher: Alejandro Lopez
Principal Investigator: Prof. Mojtaba Ghadiri
Co-Investigator(s): Prof. Kevin Roberts. Dr Ali Hassanpour
Sponsor: Advanced Manufacturing Supply Chain Initiative (AMSCI) & Medicines Manufacturing Industry Partnership (MMIP)
Status: Ongoing (June 2017 - present)Alejandro LopezAbstractThis project is part of the Advanced Digital Design of Pharmaceutical Therapeutics (ADDoPT) project, which has been funded to accelerate the translation of molecules into medicinal products. It will optimise the manufacturing processes of pharmaceutical products to effectively supply the current and next generation of medicines. It is in collaboration with AstraZeneca, Bristol-Myers Squibb, BRITEST, Cambridge Crystallographic Data Centre (CCDC),GlaxoSmithKline (GSK), Perceptive Engineering, Pfizer, Process Systems Enterprise (PSE) and the Science and Technology Facilities Council’s (SFTC) Hartree Centre together with the Universities of Cambridge and Strathclyde. In this part of the programme, predictive modelling of particle size reduction based on material science of fracture will be developed. The main focus of the project is on DEM simulation and experimental validation of Powder Flow for both cohesive and non-cohesive powders. ADDoPT Website