Modelling of Size-Reduction Processes for Pharmaceutical Materials

Researcher: Tina Bonakdar
Principal Investigator: Prof. Mojtaba Ghadiri
Co-Investigator(s): Prof. Kevin Roberts. Dr Ali Hassanpour
Sponsor: Procter and Gamble
Status: Ongoing (Apr 2016 - present)

Abstract

This project is part of the Advanced Digital Design of Pharmaceutical Therapeutics (ADDoPT) project, which has been funded to accelerate the translation of molecules into medicinal products. It will optimise the manufacturing processes of pharmaceutical products to effectively supply the current and next generation of medicines. It is in collaboration with AstraZeneca, Bristol-Myers Squibb, BRITEST, Cambridge Crystallographic Data Centre (CCDC),GlaxoSmithKline (GSK), Perceptive Engineering, Pfizer, Process Systems Enterprise (PSE) and the Science and Technology Facilities Council’s (SFTC) Hartree Centre together with the Universities of Cambridge and Strathclyde. In this part of the programme, predictive modelling of particle size reduction based on material science of fracture will be developed. The main focus of the project will be on breakage of the particles in a pin mill.